Edward Castañeda, Ph.D.
Ph.D. University of Michigan
M.A. University of Texas at El Paso
B.S. University of Texas at El Paso
Dr. Castañeda investigates plasticity in presynaptic mechanisms that modulate neurotransmitter release during changes in behavior due to neurodegeneration or substance abuse. It is interesting to speculate how fundamental mechanisms that govern learning and memory might serve for compensation in surviving dopamine neurons of the brain compromised by Parkinson's disease and how these same mechanisms might play a role in the sensitization of dopamine neurons by repeated exposure to stimulant drugs. Currently funded research seeks to understand how sensitization of amphetamine-evoked dopamine release may produce cross-sensitization to stimulant drug-conditioned environmental cues or stress. To accomplish this, Dr. Castañeda incorporates in vivo intracerebral microdialysis to collect dopamine overflow evoked by drug and electrical stimulation of dopamine pathways. Understanding the principles of cross-sensitization will provide insights regarding drug craving and recidivism in recovering addicts.
Trujillo, K.A., Castañeda, E., Martínez, D. & González, G. (2006). Biological research on drug abuse and addiction in Hispanics: current status and future directions. Drug and Alcohol Dependence, 84S:S17-S28.
Castañeda, E., Fleming, S., Paquette, M., Boat, K., Moffett, J., Stachowiak, E.K., Bloom, D.C. & Stachowiak, M.K. (2005). Gene therapy assessment in the hemiparkinson rat: drug-induced rotation is inadequate. Physiol. Behav., 84(4):525-535.
Duvauchelle, C.L., Ikegami, A. & Castañeda, E. (2000). Conditioned increases in behavioral activity and accumbens dopamine levels produced by intravenous cocaine. Behav. Neurosci., 114:1156-1166.
Duvauchelle, C.L., Ikegami, A., Asami, S., Robens, J., Kressin, K. and Castañeda, E. (2000). Effects of cocaine context on Nacc dopamine and behavioral activity after repeated intravenous cocaine administration. Brain Res., 862:49-58.