Marisela Agudelo, Ph.D.
Ph.D. in Immunology, University of South Florida
B.S. in Microbiology, University of South Florida
Overall, my research goal is to investigate the interaction between alcohol and histone deacetylases (HDACs) and their modulation of cannabinoid genes. Specifically, to measure changes in CB1, CB2, and GPR55 receptor expression in human dendritic cells and study the epigenetic mechanisms induced by alcohol.
I am a motivated young investigator who completed my graduate training in the cannabinoid research and Immunology fields with Dr. Thomas Klein at USF. Currently, I am continuing my career in the field of substance abuse as a Research Associate working with Dr. Madhavan Nair in the Department of Immunology at FIU. My current research focus combines some components from my prior work on cannabinoids with alcohol research. My future goal is to progress to a career as an independent investigator in the fields of Immunology and drug abuse research.
Agudelo M., Yoo C, and Nair, MP. (2012) “Alcohol-induced serotonergic modulation: the role of histone deacetylases” Alcohol. 46(7):635-42. PMID: 22796363
Reddy PV, Agudelo M., Atluri VS, Nair MP. (2012) Inhibition of Nuclear Factor Erythroid 2-Related Factor 2 Exacerbates HIV-1 gp120-Induced Oxidative and Inflammatory Response: Role in HIV Associated Neurocognitive Disorder. Neurochem Res. 37(8):1697-706. PMID: 22528837
Reddy PV, Samikkannu T, Gandhi N, Saiyed Z, Agudelo M, Khatavkar P, Yndart A, and Nair MP. (2012). HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: Role in HIV associated neurocognitive disorder. Neurochem. Intl. 61(5):807-14. PMID: 21756955
Agudelo M, Gandhi N, Saiyed Z, Pichili V, Samikkannu T, Khatavkar P, Yndart-Arias A, Nair M. (2011). Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin (TSA). Alcohol Clin. Exp. Res. 35(8):1550-6. PMID: 21447001
Saiyed Z., Gandhi N, Agudelo M, Napuri J, Samikkannu T, Reddy P, Khatavkar P Yndart A, Saxena S, and Nair M. (2011) "HIV-1 Tat Upregulates Expression of Histone Deacetylase-2 (HDAC2) in Human Neurons: Implication for HIV-Associated Neurocognitive Disorder (HAND)" Neurochemistry International. 58(6):656-64. PMID: 21315782
Samikkannu T, Agudelo M, Gandhi N, Reddy PV, Saiyed ZM., Nwankwo D, Nair MP. (2011). Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS. J. Neurovirol. 17(3):230-8. PMID: 21491143