Kalírís Y. Salas-Ramírez, Ph.D.
Ph.D. (ABD) Michigan State University
B.S. University of Puerto Rico – Rio Piedras
Dr. Salas-Ramirez's research interests are to understand how drugs of abuse impact the brain at different times of development. Her doctoral dissertation focused on studying how the adolescent brain is different than the adult brain by looking at the immediate and long-term effects of anabolic steroids on social behaviors and neurogenesis in a rodent model. These studies determined that the adolescent brain is more vulnerable to the long-lasting effects of steroids by showing a marked increase in aggressive behaviors in adulthood after adolescent exposure. Her work as a post doc at Sophie Davis extended that work by looking at prenatal, adolescent and adult cocaine exposure and its effects on adult cognition. This work has established that cocaine exposure during prenatal and adolescent development causes long-term cognitive deficits in adult rodents. In addition, another component of her work is to understand sex differences after cocaine exposure. Current and future projects are focused on investigating the mechanisms by which cocaine impacts neural plasticity, that in turn can impact behavior.
Delorme, KC, Schulz, KM, Salas‐Ramirez, KY*, Sisk, CL. Pubertal testosterone organizes regional volume and neuronal number within the medial amygdala of adult male Syrian hamsters. Brain Research, Jun 15;1460:33‐40. Epub 2012 Apr 26
Frankfurt, M, Salas‐Ramirez, KY*, Friedman, E and Luine, VN. Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat. Synapse, Sep 2011;65 (9):955‐61. Epub 2011 Apr 7.
Salas‐Ramirez, KY*, Frankfurt, M, Alexander, A , Luine, VN and Friedman, E. Prenatal cocaine exposure increases anxiety, impairs cognitive function and increases dendritic spine density in adult rats. Neuroscience. 2010 Sep 1;169 (3):1287‐95. Epub 2010 May 27.
Salas‐Ramirez, KY*, Montalto, PR and Sisk, CL. Anabolic steroids produce long‐lasting effects on social behaviors in male Syrian Hamsters. Behavioural Brain Research. 2009 Apr 2; 208 (2):328‐35. Epub 2009 Dec 30. (press‐release in Miller‐McCune Online Newsletter: http:// miller‐mccune.com/mice/teen‐steroid‐use‐suppressessubmissiveness‐1716)
Schulz, KM, Zehr, JL, Salas‐Ramirez, KY* and Sisk, CL. Testosterone programs adult social behavior before and during, but not after, adolescence. Endocrinology. 2009 Aug; 150 (8):3690‐8.
Salas‐Ramirez, KY*, Montalto, PR and Sisk, CL. Anabolic androgenic ateroids differentiallly affect social behaviors in adolescent and adult male Syrian hamsters. Hormones and Behavior. 2008 Feb; 53 (2):378‐85.